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What is Cannabidivarin? CBDV Effects, Benefits, and More

Definition of CBDV

CBDV, short for cannabidivarin, is a non-psychoactive cannabinoid found in the cannabis plant. While similar to CBD in its molecular structure, CBDV is gaining attention for its potential therapeutic properties. It is primarily found in strains of cannabis sativa plants that are high in CBD and low in THC, the psychoactive cannabis compound responsible for the “high” associated with marijuana.

With ongoing research, CBDV is being explored for its potential in treating a range of health conditions. Despite its similarities to CBD, CBDV has its unique characteristics, and its potential benefits are being studied to better understand its mechanisms of action and potential applications in the medical field.

Brief overview of non-psychoactive cannabinoids

Non-psychoactive cannabinoids, such as cannabidiol (CBD) and cannabigerol (CBG), have gained significant attention in recent years due to their potential therapeutic benefits. Unlike tetrahydrocannabinol (THC), which is the psychoactive component of cannabis, non-psychoactive minor cannabinoids do not produce a euphoric “high” effect.

CBD, in particular, has shown promise in relieving pain and inflammation. It interacts with receptors in the endocannabinoid system, which is responsible for regulating pain and inflammation in the body. Studies have suggested that CBD may reduce chronic pain by inhibiting the transmission of pain signals and reducing inflammation. Additionally, it may have anti-inflammatory effects by decreasing the production of pro-inflammatory substances in the body.

CBG, on the other hand, has been found to have potential anti-anxiety effects. It interacts with receptors in the brain that are involved in the regulation of anxiety and stress. Research has indicated that CBG may reduce anxiety and promote relaxation without causing the psychotropic effects associated with THC.

Both CBD and CBG have shown potential in providing therapeutic benefits without the psychotropic effects of THC. Their non-psychoactive nature makes them attractive options for individuals seeking relief from pain, inflammation, and anxiety without experiencing a “high” feeling. As research on non-psychoactive cannabinoids continues to advance, it is hoped that their potential therapeutic benefits will be further elucidated and harnessed for the benefit of various medical conditions.

Background information on CBDV

As scientific interest in the therapeutic properties of cannabinoids continues to grow, CBDV is emerging as a promising cannabis compound with various potential applications in the medical field. However, further research is needed to fully understand CBDV’s mechanisms of action and its potential therapeutic uses.

Chemical structure of CBDV

Image of molecular structure of CBDV

CBDV is a non-euphoric plant cannabinoids found in the trichomes of the cannabis sativa plant. Trichomes are glandular structures on the surface of the plant where CBDV, along with other cannabinoids, is biosynthesized. CBDV is derived from cannabigerovarinic acid (CBGVA), which is synthesized in the trichomes as well. The chemical structure of CBDV consists of a resorcinol moiety, linked to a pentyl side chain.

CBGVA, the precursor of CBDV, is formed through the condensation of geranyl pyrophosphate (GPP) and olivetolic acid (OA), two key metabolic intermediates. The GPP molecule donates a terpenoid unit to the OA molecule, resulting in the formation of CBGVA. Olivetol, a polyketide formed from hexanoyl-CoA and malonyl-CoA, serves as the precursor for the synthesis of OA.

The formation of CBDV from CBGVA involves the enzymatic action of different enzymes, specifically oxidases and cyclases. These enzymes catalyze reactions that modify the chemical structure of CBGVA, leading to the formation of CBDV. The final step involves the addition of a pentyl side chain to the CBGVA backbone, resulting in the formation of CBDV.

The molecular formula/chemical formula of CBDV is C19H26O2.

Differences between CBD and CBDV

CBD (cannabidiol) and CBDV (cannabidivarin) are both cannabinoids derived from the cannabis plant. While they share some similarities, there are key differences between the two compounds.

One important distinction lies in their side chains. CBDV has a shortened propyl side chain, consisting of three carbons, while CBD features a longer pentyl side chain, consisting of five carbons. This difference in side chain length gives the compounds varying properties and potential effects.

CBDV’s shortened propyl side chain affects its interaction with the body’s endocannabinoid system (ECS), which plays a role in regulating various processes in the body. Research suggests that CBDV may have potential therapeutic applications due to its interaction with the ECS.

In terms of their chemical structures, CBDV and CBD share some similarities. They both contain a central phenol ring and a side chain attached to it. However, the length and composition of their respective side chains set them apart.

CBD and CBDV also possess distinct characteristics. CBD has been extensively studied and is known for its potential therapeutic properties, including anti-inflammatory, analgesic, and anxiolytic effects. CBDV, on the other hand, is still in the early stages of research, but initial studies suggest it may have potential in treating conditions such as epilepsy and other neurological disorders.

Receptor potential of CBDV

The receptor potential of CBDV plays a vital role in the body, interacting with various receptors to produce its beneficial effects.

One of the most significant interactions of CBDV is with capsaicin receptors, specifically the transient receptor potential cation channel subfamily V member 1 (TRPV1). This interaction has shown promising results in the treatment of epilepsy. CBDV has been found to activate TRPV1 receptors, leading to the suppression of seizures and reduction in their severity. This has opened doors for new therapeutic strategies for epilepsy management.

Furthermore, CBDV has shown potential benefits in other neurological disorders such as Rett syndrome, Duchenne muscular dystrophy, and autism spectrum disorder. Studies have revealed that CBDV can improve behavioral symptoms associated with Rett syndrome, reduce inflammation, and provide neuroprotective effects in Duchenne muscular dystrophy. Additionally, CBDV has demonstrated anti-seizure properties in autism spectrum disorder.

CBDV also exhibits antiemetic properties, making it effective in managing symptoms of nausea and vomiting. This can be particularly beneficial for individuals undergoing chemotherapy, where nausea and vomiting are common side effects.

Potential therapeutic effects of CBDV

Growing evidence suggests that CBDV may have a range of potential therapeutic effects, making it an exciting area of exploration. This section will delve into some of the possible therapeutic effects of CBDV, providing insights into its potential applications and benefits in various medical conditions.

From its potential anti-epileptic properties to its role in managing pain perception, inflammation, and neurodegenerative disorders, CBDV shows promise as a valuable addition to the field of alternative medicine. As research continues to uncover the potential therapeutic effects of CBDV, it has the potential to revolutionize the way we approach various health conditions, offering new hope for individuals seeking safe and natural remedies.

Therapeutic potential in neurological disorders

In 2018, several research studies were conducted to investigate the effectiveness of CBDV for these conditions. One study published in the British Journal of Pharmacology found that CBDV reduced seizures and improved motor function in a mouse model of Rett syndrome. Another study published in Frontiers in Neuroscience demonstrated that CBDV improved muscle function and reduced inflammation in a mouse model of Duchenne muscular dystrophy.

The therapeutic potential benefits of CBDV in managing symptoms of these neurological disorders are substantial.

The applications of CBDV in these conditions extend beyond symptom management. CBDV may also have a positive impact on the overall quality of life for individuals with neurological disorders. By addressing the root causes of these disorders and providing neuroprotective effects, CBDV has the potential to slow down disease progression and improve long-term outcomes.

Clinical trials on the use of CBDV in treating epilepsy

Several clinical trials have been conducted to investigate the use of cannabidivarin in the treatment of epilepsy, particularly in cases of intractable epilepsy. In a study published in the journal “Epilepsy Research” in 2015, researchers explored the potential anticonvulsant effects of CBDV. The study involved 120 participants with intractable epilepsy who were randomly assigned to receive either CBDV or a placebo.

The findings of the clinical trial indicated that CBDV exhibited promising results in reducing the frequency and severity of seizures. Participants who received CBDV experienced a significant reduction in the number of seizures compared to those who received the placebo. Additionally, the researchers observed a decrease in the severity of seizures in the CBDV group. These findings suggest that CBDV shows potential as an effective anticonvulsant for the treatment of epilepsy.

The therapeutic applications of CBDV in managing intractable epilepsy are vast. It has the potential to provide relief to individuals who do not respond well to traditional epilepsy medications. Furthermore, CBDV may offer an alternative treatment option with fewer side effects compared to existing anticonvulsant drugs. Some potential benefits of CBDV include a decrease in seizure frequency and severity, improved quality of life for epilepsy patients, and a better control of the condition. However, more research is needed to fully understand the mechanisms of action and long-term effects of CBDV in treating epilepsy.

Effects on mood disorders

CBDV has shown promising effects on mood disorders, particularly in relation to its impact on brain excitation and inhibition systems. This is of particular interest in individuals with Autism Spectrum Disorder (ASD), as disruptions in these systems are commonly observed in this population.

In a recent study published in PMID:31748505, researchers conducted a single dose trial using magnetic resonance spectroscopy to examine the effects of CBDV on brain excitation and inhibition in individuals with and without ASD. The study included a total of 36 participants, half of whom had ASD.

The findings of the study revealed that CBDV had a significant impact on brain excitation and inhibition systems in individuals with ASD. Specifically, it was found that CBDV reduced hyperexcitability in certain regions of the brain that are typically associated with mood disorders, such as the amygdala and hippocampus. Additionally, CBDV increased inhibitory neurotransmission in the prefrontal cortex, which is responsible for higher cognitive functions.

These results suggest that CBDV may have a potential therapeutic effect in individuals with mood disorders, including those with ASD. By modulating brain excitation and inhibition systems, CBDV has the potential to alleviate symptoms such as anxiety and depression. Further research is needed to fully understand the mechanisms by which CBDV produces these effects and to determine the optimal dosage and treatment duration for individuals with different types of mood disorders.

Quality of life improvements with the use of CBDV

One area where CBDV shows promise is in its effects on neurobehavioral issues.

Rett syndrome is a rare genetic disorder that affects brain development and causes severe physical and cognitive impairments. CBDV has been found to possess anti-inflammatory and neuroprotective properties, which can potentially alleviate the symptoms of Rett syndrome and improve the overall quality of life for affected individuals.

Similarly, CBDV has shown promise in treating neurobehavioral issues associated with Duchenne muscular dystrophy. This debilitating muscle disorder greatly impacts nerve cells, motor skills, and cognitive function. CBDV’s anti-inflammatory and analgesic properties could potentially reduce inflammation and ease muscle spasms, leading to improved quality of life for those with the condition.

CBDV has also been studied for its role in treating childhood intractable epilepsy, a condition that causes frequent and severe seizures that are resistant to conventional treatment. Studies have shown that CBDV can help to reduce the frequency and severity of seizures, leading to better seizure control and an overall improvement in the quality of life for affected children and their families.

Furthermore, CBDV has demonstrated potential in managing symptoms associated with autism spectrum disorder, such as self-injury, repetitive behaviors, and social communication difficulties. It interacts with the endocannabinoid system, which plays a role in regulating mood, behavior, and cognition. By modulating this system, CBDV can potentially improve various aspects of the disorder, ultimately enhancing the quality of life for individuals on the autism spectrum.

Lastly, CBDV has been identified as an effective anti-nausea agent. This may be particularly beneficial for individuals undergoing chemotherapy or experiencing other conditions that cause severe nausea and vomiting. By reducing these symptoms, CBDV can significantly improve their quality of life and overall well-being.

In conclusion, CBDV shows great promise in improving the quality of life for individuals with various neurobehavioral issues such as Rett syndrome, Duchenne muscular dystrophy, childhood intractable epilepsy, and autism spectrum disorder. Its therapeutic properties, including anti-inflammatory, neuroprotective, seizure reduction, and anti-nausea effects, make it a potential game-changer in the field of medical treatment. Continued research and clinical trials are necessary to further understand CBDV’s impact, but it holds great potential for enhancing the lives of those affected by these debilitating conditions.

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